June 04, 2021 3 min read

Have you ever wondered, "how is this CBD regulating my immune system responses?" "Is it helping or hurting my immune system?"  Did you know that scientists consider the endocannabinoid system, known for its role in regulating your immunity, as the gatekeeper of the immune system? The endocannabinoid system consists of receptors known as cannabinoid receptors (CB1 and CB2), which include the endogenous cannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG), as well as enzymes that regulate the production of these endocannabinoids.

There is, however, scientific evidence that cells in your immune system may express both CB1 and CB2, with CB2 concentrations being a bit higher than CB1.

CBD and Immune System Interactions

Cannabidiol (CBD) is a non-psychoactive element of Cannabis sativa, a phytocannabinoid that acts upon the endocannabinoid system and possesses the capability to maintain a healthy and balanced immune system.

CBD triggers TRPV2 as well as influencing other transient receptor potential (TRP) channels involved in supporting your immune system. The transient receptor potential vanilloid 2 (TRPV2), which is a protein that helps the communication of cells with their extracellular environs. It also plays a crucial role in the functioning of a healthy immune system.

CBD oils based with hemp may have both indirect and direct mechanisms for ensuring healthy immunity. Can CBD help support and maintain a healthy functioning immune system? Let's delve in a little into the topic and find out with Transformative Health.

Increase Killer Cells, Naturally

Natural Killer (NK) cells are instrumental in how the body responds to the exposure of viruses. CBD additionally affirms the involvement of the natural killer T cells, which both share the properties of T cells and NK cells. 

CBD oil from hemp has been shown to be successful at balancing your immune system by reducing the activity of B and T cells, including both T helper and T cytotoxic lymphocyte subsets activity. But when not in an autoimmune state, CBD can support the activity of natural killer (NK) cells, which is a form of white blood cell.

CBD and a Healthy Inflammatory Response

CBD is touted for its ability to manage a healthy inflammatory response. As shown in animal studies, CBD was shown to support a healthy inflammatory response and improved lung function in mice that were exposed to irritants.

Did you know that a large majority of your immune system is situated within your GI tract? There are also sizable numbers of organized lymphoid tissue, adaptive effector cells and scattered innate cells. The gut microbiota, which is a library of good and bad organisms, and is located in the intestines also play an essential part assisting the body in maintaining balanced immune responses.

Excess inflammation in the gut can lead to leaky gut, gut microbiota dysbiosis, and an impaired intestinal immune response. The body neutralizes this through the endocannabinoid system. CBD has also been known to support healthy inflammatory responses in human trials.

CBD and its Calming Effects 

Persistent stress can cause a decline in your immune response, and CBD has been known for providing healthy stress related responses mentally and physically. 

CBD's stress-relieving properties are associated with its capability of modulating the cerebral blood flow in regions of the brain involved in anxiety. CBD supplementation has been shown to lead to the direct activation of the 5-HT1A serotonin receptor. This is different from the endogenous cannabinoids, which tend to work on the CB1 receptor. CBD was also discovered to reduce mild stress in human trials.

Next Steps

If you're living with chronic pain and have been considering alternative health and wellness techniques for the management of your pain, or if you simply have questions about how alternative medicine can help, schedule your visit with Transformative Health today. We look forward to helping you feel better by living your best life.  In the meantime, consider checking out our blog over here.